The school is located in an area called F.t. Chicken, Illinois, where a young girl is seen to eat a tainted chicken nugget (which we were lucky enough to see the entire process of in the first scene). This girl then goes on to infect other children in the school.
Clint Hadson (Elijah Wood) is a struggling writer who is subbing as an elementary teacher to pay the bills. He has the lucky task of dealing with a bunch of badly behaved 4th graders, made only better by the outbreak of the maddening, bloodthirsty disease.
This film is a little weird. All of the teachers are ridiculously quirky and odd and the disease only appears to infect children, meaning that the film unfolds into an entertaining, zombified Children of the Corn scenario. The characters are possibly too caricature-ish to care too much about, but on the whole the film is gross, silly and entertaining. There were also very self-aware jabs at Elijah Wood (who owns SpectreVision, coincidentally) throughout.
Whilst it's a bit of a one-trick pony, "Cooties" delivers some light-hearted, gory fun.